Tg(tetO-lacZ,-SHANK2_iA*,-Venus)2Rsp
Transgene Detail

Summary

• Symbol: Tg(tetO-lacZ,-SHANK2_iA*,-Venus)2Rsp
• Name: transgene insertion 2, Rolf Sprengel
• MGI ID: MGI:7567843
• Synonyms: Tg^{SHANK2A(R462X)}
• Transgene: Tg(tetO-lacZ,-SHANK2_iA*,-Venus)2Rsp Location: unknown
• Alliance: Tg(tetO-lacZ,-SHANK2_iA*,-Venus)2Rsp page

Transgene origin

• Strain of Origin: C57BL6/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(tetO-lacZ,-SHANK2_iA*,-Venus)2Rsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SHANK2 (22941)

  Shank2

  (MGI:2671987)

• Mutation details: The transgene contains a bi-directional tetracycline-responsive promoter element controlling the expression of the nuclear-localized beta-galactosidase (nLacZ) on one side and fusion transcript composed of green fluorescent protein variant (Venus), fused via the ribosomal skipping sequence T2A to the brain-specific isoform (A) of the human gene with the mutation responsible for the amino acid substitution of arginine with a stop codon at position 462 (R462*). (J:310967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:310967 Eltokhi A, et al., Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders. Mol Psychiatry. 2021 May 21
• All: 1 reference(s)