Gipr^em1Temc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gipr^em1Temc
• Name: gastric inhibitory polypeptide receptor; endonuclease-mediated mutation 1, Timothy E McGraw
• MGI ID: MGI:7567367
• Synonyms: GIPR-Q350
• Gene: Gipr Location: Chr7:18889986-18900052 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gipr^em1Temc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Glutamic acid codon 350 (GAG) in exon 12 was changed to glutamine (CAG) (p.E350Q) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.E354Q mutation (SNP rs1800437) associated with a lower body mass index (BMI) and increased risk for type 2 diabetes (T2D). (J:342957)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gipr Mutation: 28 strains or lines available

References

• Original: J:342957 Yammine L, et al., Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. Mol Metab. 2023 Dec;78:101831
• All: 1 reference(s)