Tg(tetO/CMV-MANF)#Mlin
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-MANF)#Mlin
• Name: transgene insertion, Maria Lindahl
• MGI ID: MGI:7565868
• Synonyms: TET-MANF Tg
• Transgene: Tg(tetO/CMV-MANF)#Mlin Location: unknown
• Alliance: Tg(tetO/CMV-MANF)#Mlin page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-MANF)#Mlin expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MANF (7873)

  Manf	(MGI:1922090)

• Mutation details: The full-length human MANF cDNA was inserted between seven direct repeats of the tet-operator sequence/CMV promoter and the mouse protamine 1 polyA and intron sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:343282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:343282 Kim Y, et al., MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Nat Commun. 2023 Oct 14;14(1):6493
• All: 1 reference(s)