Aktip^{tm1d(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Aktip^{tm1d(EUCOMM)Hmgu}
• Name: AKT interacting protein; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7565695
• Gene: Aktip Location: Chr8:91834267-91862122 bp, - strand Genetic Position: Chr8, 44.25 cM
• Alliance: Aktip^{tm1d(EUCOMM)Hmgu} page
• IMPC: Aktip gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342965
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The Aktip^{tm1a(EUCOMM)Hmgu} allele (MGI:4435660) was FLP excised removing the neo selection cassette and lacZ reporter leaving behind the floxed critical exon(s). Cre-mediated recombination removed the critical exons. (J:342965)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aktip Mutation: 21 strains or lines available

References

• Original: J:342965 La Torre M, et al., Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1. Aging Cell. 2023 Nov 13;:e14022
• All: 1 reference(s)