Sting1^tm1.1Ccah
Targeted Allele Detail

Summary

• Symbol: Sting1^tm1.1Ccah
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 1.1, Chih-Chi Andrew Hu
• MGI ID: MGI:7565684
• Synonyms: STING V154M
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm1.1Ccah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Valine codon 154 (GTT) in exon 5 was changed to methionine (ATG) (p.V154M) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 5. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation renders the encoded peptide constitutively active. (J:343151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

References

• Original: J:343151 Tang CA, et al., STING regulates BCR signaling in normal and malignant B cells. Cell Mol Immunol. 2021 Apr;18(4):1016-1031
• All: 1 reference(s)