App^tmTtom
Targeted Allele Detail

Summary

• Symbol: App^tmTtom
• Name: amyloid beta precursor protein; targeted mutation 1, Takami Tomiyama
• MGI ID: MGI:7565564
• Synonyms: OSK-KI
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tmTtom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342281
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 17 was replaced with mouse exon 17 containing the Osaka mutation, which is a deletion of codon 693 (GAA), and a loxP-flanked PGK-neo cassette. (J:342281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 118 strains or lines available

References

• Original: J:342281 Umeda T, et al., Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Acta Neuropathol Commun. 2017 Jul 31;5(1):59
• All: 1 reference(s)