Brca2tm3.1Sks
Targeted Allele Detail
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Symbol: |
Brca2tm3.1Sks |
Name: |
breast cancer 2, early onset; targeted mutation 3.1, Shyam K Sharan |
MGI ID: |
MGI:7565556 |
Synonyms: |
Brca2R2971Q, Brca2RQ |
Gene: |
Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
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Alliance: |
Brca2tm3.1Sks page
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An AGG to CAG change resulting in an arginine to glutamine substitution at amino acid 2971 (p.R2971Q) was introduced in exon 24. A loxP-PGK-Tn5-neomycin-bp(A)-loxP site cassette was inserted in intron 24. The neomycin cassette was removed via cre-mediated recombination. This is equivalent to R3052Q in human BRCA2.
(J:342841)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Brca2 Mutation: |
132 strains or lines available
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Original: |
J:342841 Mishra AP, et al., Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant. Cell Death Dis. 2023 Nov 18;14(11):753 |
All: |
1 reference(s) |
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