Kmt2c^em1Kaig
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmt2c^em1Kaig
• Name: lysine (K)-specific methyltransferase 2C; endonuclease-mediated mutation 1, Kai Ge
• MGI ID: MGI:7565498
• Synonyms: Mll3^KI, MLL3 Y4792A
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^em1Kaig page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Tyrosine codon 4793 (TAC) in exon 56 was changed to alanine (GCT) (p.Y4793A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation creates a enzyme-dead version of the encoded peptide. (J:342639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 182 strains or lines available

References

• Original: J:342639 Xie G, et al., MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner. Nat Genet. 2023 Apr;55(4):693-705
• All: 1 reference(s)