Pten^tm2.2Ppp
Targeted Allele Detail

Summary

• Symbol: Pten^tm2.2Ppp
• Name: phosphatase and tensin homolog; targeted mutation 2.2, Pier Paolo Padolfi
• MGI ID: MGI:7565452
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2.2Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295972
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed CMV-neo cassette was inserted into intron 3 and a loxP site into intron 5. The floxed neo cassette was removed via cre-mediated recombination leaving exons 4-5 floxed which were deleted via cre-mediated recombination. (J:295972)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm2.2Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:295972 Li Q, et al., Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20538-20548
• All: 1 reference(s)