Tm2d3^em1Mkit
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm2d3^em1Mkit
• Name: TM2 domain containing 3; endonuclease-mediated mutation 1, Motoo Kitagawa
• MGI ID: MGI:7565299
• Gene: Tm2d3 Location: Chr7:65343204-65351650 bp, + strand Genetic Position: Chr7, 35.26 cM, cytoband C
• Alliance: Tm2d3^em1Mkit page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to delete a segment of the gene that contained the exon 5, which encodes a part of the transmembrane domains that are required for activation. (J:343264)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm2d3 Mutation: 18 strains or lines available

References

• Original: J:343264 Masuda W, et al., TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. Sci Rep. 2023 Nov 27;13(1):20913
• All: 1 reference(s)