Tshr^em1Cnbc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tshr^em1Cnbc
• Name: thyroid stimulating hormone receptor; endonuclease-mediated mutation 1, Centro Nacional de Biotecnologia
• MGI ID: MGI:7565285
• Gene: Tshr Location: Chr12:91367767-91507283 bp, + strand Genetic Position: Chr12, 44.51 cM
• Alliance: Tshr^em1Cnbc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9-targeting introduces the mutation for the amino acid substitution of methionine with threonine at position 453 (Met453Thr). (J:363400)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tshr Mutation: 11 strains or lines available

References

• Original: J:363400 Makkonen K, et al., Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model. JCI Insight. 2024 Jan 9;9(4)
• All: 1 reference(s)