Scn10a^tm1.1Yah
Targeted Allele Detail

Summary

• Symbol: Scn10a^tm1.1Yah
• Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 1.1, Yann Herault
• MGI ID: MGI:7564596
• Synonyms: Scn10a^G1663S
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^tm1.1Yah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Glycine codon 1663 (GGC) in exon 28 was changed to serine (AGC) (p.G1663S) and a loxP site, a neomycin resistance gene cassette, a cre gene cassette and a second loxP site were inserted into intron 27. The neo and cre cassettes auto-excised. The mutation is the equivalent of the human p.G1662S gain-of-function mutation associated with idiopathic painful small fiber neuropathy (SFN). (J:342722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 107 strains or lines available

References

• Original: J:342722 Chidiac C, et al., The Human SCN10A(G1662S) Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity. Front Pharmacol. 2021;12:780132
• All: 1 reference(s)