Gata2^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Nju
• Name: GATA binding protein 2; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7564547
• Synonyms: GATA^L359V
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Leucine codon 359 (TTA) in exon 5 was changed to valine (GTA) (p.L359V) and a loxP site flanked neomycin resistance gene was inserted into an intron. The mutation is the equivalent of the same human mutation associated with acute myeloid leukemia (AML) and myelomonocytic transformation of chronic myelogenous leukemia (CML). (J:342777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 29 strains or lines available

References

• Original: J:342777 Fu YK, et al., Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model. Cell Death Dis. 2021 Jun 2;12(6):568
• All: 1 reference(s)