Tg(Prnp*D177N*M128V)66Rchi
Transgene Detail

Summary

• Symbol: Tg(Prnp*D177N*M128V)66Rchi
• Name: transgene insertion 66, Roberto Chiesa
• MGI ID: MGI:7564283
• Transgene: Tg(Prnp*D177N*M128V)66Rchi Location: unknown
• Alliance: Tg(Prnp*D177N*M128V)66Rchi page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*D177N*M128V)66Rchi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: Site directed mutagenesis was used to generate a murine Prnp gene homologous to the D178N/V129 human variants linked to Creutzfeldt-Jakob disease. Five founder lines were created with this line containing 22 copies of the transgene. Transgenic protein levels in hemizygote brain were similar to endogenous protein levels, with about 50% of transgenic protein being insoluble. (J:142098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 5 reference(s)