Aspn^tm1.1Mmac
Targeted Allele Detail

Summary

• Symbol: Aspn^tm1.1Mmac
• Name: asporin; targeted mutation 1.1, Marco Maccarana
• MGI ID: MGI:7564241
• Synonyms: Aspn^f
• Gene: Aspn Location: Chr13:49697919-49721041 bp, + strand Genetic Position: Chr13, 25.31 cM, cytoband B1
• Alliance: Aspn^tm1.1Mmac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2-3 were flanked by loxP sites and a neomycin selection cassette flanked by FRT sites was inserted upstream of the second loxP site. The neomycin cassette was removed via flp-mediated recombination. (J:341806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspn Mutation: 28 strains or lines available

References

• Original: J:341806 Maccarana M, et al., Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS One. 2017;12(8):e0184028
• All: 1 reference(s)