Cnot7^tm1.2Tya
Targeted Allele Detail

Summary

• Symbol: Cnot7^tm1.2Tya
• Name: CCR4-NOT transcription complex, subunit 7; targeted mutation 1.2, Tadashi Yamamoto
• MGI ID: MGI:7562478
• Synonyms: Cnot7 KO
• Gene: Cnot7 Location: Chr8:40945581-40968888 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Cnot7^tm1.2Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343009
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A conditional allele was generated by flanking a critical exon(s) with loxP sites (further molecular details are not specified). Flp-mediated recombination removed a co-inserted selection cassette. Cre-mediated recombination removed the floxed exon(s) in the germline. (J:343009)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot7 Mutation: 27 strains or lines available

References

• Original: J:343009 Soeda S, et al., The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs. Development. 2023 Nov 1;150(21):dev201773
• All: 1 reference(s)