Arid4b^tm1.2Mywu
Targeted Allele Detail

Summary

• Symbol: Arid4b^tm1.2Mywu
• Name: AT-rich interaction domain 4B; targeted mutation 1.2, Mei-Yi Wu
• MGI ID: MGI:7562403
• Gene: Arid4b Location: Chr13:14238334-14374188 bp, + strand Genetic Position: Chr13, 5.29 cM
• Alliance: Arid4b^tm1.2Mywu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250205
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upsteam of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette and exon 1. (J:250205)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid4b Mutation: 67 strains or lines available

References

• Original: J:250205 Wu RC, et al., Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network. Stem Cells. 2017 Jun;35(6):1554-1565
• All: 1 reference(s)