Nfatc1^em1Kosa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfatc1^em1Kosa
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 1, Kojiro Sato
• MGI ID: MGI:7562396
• Synonyms: Nfatc1 ex1-
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^em1Kosa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second ATG codon in exon 1 was replaced with a 9 bp sequence containing a stop codon via CRISPR/Cas9 technology. This generates a knock-out of the short isoform. (J:342901)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:342901 Omata Y, et al., Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation. Sci Rep. 2023 Nov 1;13(1):18797
• All: 1 reference(s)