Stat3^em1Jyue
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stat3^em1Jyue
• Name: signal transducer and activator of transcription 3; endonuclease-mediated mutation 1, Jicheng Yue
• MGI ID: MGI:7562330
• Synonyms: Stat3^T716E
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^em1Jyue page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a threonine to glutamic acid substitution at amino acid 716 (pT716E). Transcriptional activity of Stat3 is significantly reduced. (J:342942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:342942 Wang Y, et al., The mechanism underlying the inverse proportion between serum IgE concentration and Stat3 transcriptional activity depends on Stat3 mutation type. Int Immunopharmacol. 2023 Nov;124(Pt B):111031
• All: 1 reference(s)