Fbp1^tm1.1Mcs
Targeted Allele Detail

Summary

• Symbol: Fbp1^tm1.1Mcs
• Name: fructose bisphosphatase 1; targeted mutation 1.1, M Celeste Simon
• MGI ID: MGI:7562325
• Synonyms: Fbp1^flox
• Gene: Fbp1 Location: Chr13:63012567-63036096 bp, - strand Genetic Position: Chr13, 32.74 cM, cytoband B3-C1
• Alliance: Fbp1^tm1.1Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291125
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The core promoter and exon 1 were flanked by loxP sites and an FRT-flanked neomycin cassette was inserted upstream of the second loxP site. The neomycin selection cassette was removed via flp-mediated recombination. (J:291125)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbp1 Mutation: 25 strains or lines available

References

• Original: J:291125 Li F, et al., FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome. Nat Cell Biol. 2020 Jun;22(6):728-739
• All: 3 reference(s)