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Ackr3tm2.1Stum
Targeted Allele Detail
Summary
Symbol: Ackr3tm2.1Stum
Name: atypical chemokine receptor 3; targeted mutation 2.1, Ralf Stumm
MGI ID: MGI:7562045
Synonyms: Ackr3STA, HA-Ackr3STA, HA-ACKR3-ST/A
Gene: Ackr3  Location: Chr1:90131702-90143446 bp, + strand  Genetic Position: Chr1, 45.28 cM
Alliance: Ackr3tm2.1Stum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:275611
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Epitope tag)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsSequence coding for an HA tag was inserted immediately downstream of the ATG start codon in exon 2, a loxP site flanked neomycin resistance gene cassette was inserted into intron 1 and the following mutations were engineered in exon 2: serine codons 535 (TCG), 347 (TCC), 350 (TCA) and 355 (TCT) and threonine codons 338 (ACA), 341 (ACC), 352 (ACA) and 361 (ACC) were changed to alanine (p.S335A, p.S347A, p.S350A, p.S355A, p.T338A, p.T341A, p.T352A and p.T361A). The neo cassette was removed through subsequent Cre-mediated recombination. The mutations block phosphorylation of the affected residues in the encoded peptide. (J:275611)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ackr3 Mutation:  34 strains or lines available
References
Original:  J:275611 Saaber F, et al., ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not beta-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory