Zc3h12a^tm1.1Aki
Targeted Allele Detail

Summary

• Symbol: Zc3h12a^tm1.1Aki
• Name: zinc finger CCCH type containing 12A; targeted mutation 1.1, Shizuo Akira
• MGI ID: MGI:7562023
• Synonyms: Regnase-1^AA
• Gene: Zc3h12a Location: Chr4:125012216-125021633 bp, - strand Genetic Position: Chr4, 58.1 cM
• Alliance: Zc3h12a^tm1.1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Serine codons 435 (TCA) and 439 (TCC) in exon 6 were changed to alanine (GCA, GCC) (p.S435A, p.S439A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 5. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations block phosphorylation of the affected residues in the encoded peptide. (J:277918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zc3h12a Mutation: 34 strains or lines available

References

• Original: J:277918 Tanaka H, et al., Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. J Exp Med. 2019 Jun 3;216(6):1431-1449
• All: 2 reference(s)