Ltbp4^tm1.1Brada
Targeted Allele Detail

Summary

• Symbol: Ltbp4^tm1.1Brada
• Name: latent transforming growth factor beta binding protein 4; targeted mutation 1.1, Branka Dabovic
• MGI ID: MGI:7561923
• Synonyms: Ltbp4^CC>SS
• Gene: Ltbp4 Location: Chr7:27004561-27037117 bp, - strand Genetic Position: Chr7, 15.87 cM
• Alliance: Ltbp4^tm1.1Brada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279186
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cysteine codons 1235 (TGT) and 1260 (TGC) in exon 26 were changed to serine (AGT, AGC) (p.C1235S, p.C1260S) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 25. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations, in the TGFB-binding 8-cysteine domain of the encoded peptide, blocks TGFB binding. (J:279186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbp4 Mutation: 140 strains or lines available

References

• Original: J:279186 Dabovic B, et al., Function of latent TGFbeta binding protein 4 and fibulin 5 in elastogenesis and lung development. J Cell Physiol. 2015 Jan;230(1):226-36
• All: 3 reference(s)