Reln^tm1.1Eso
Targeted Allele Detail

Summary

• Symbol: Reln^tm1.1Eso
• Name: reelin; targeted mutation 1.1, Eduardo Soriano
• MGI ID: MGI:7550837
• Synonyms: Reelin^F
• Gene: Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
• Alliance: Reln^tm1.1Eso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 1. The neomycin cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:328938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reln Mutation: 209 strains or lines available

References

• Original: J:328938 Vilchez-Acosta A, et al., Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2120079119
• All: 1 reference(s)