Bcl2l1^tm1.1Jusa
Targeted Allele Detail

Summary

• Symbol: Bcl2l1^tm1.1Jusa
• Name: BCL2-like 1; targeted mutation 1.1, Junichi Sadoshima
• MGI ID: MGI:7550776
• Synonyms: Bcl-xL S14A KI
• Gene: Bcl2l1 Location: Chr2:152622588-152673648 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H1
• Alliance: Bcl2l1^tm1.1Jusa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290419
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Serine codon 14 (TCC) in exon 2 was changed to alanine (GCC) (p.S14A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 2. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation prevents phosphorylation of the affected residue in the encoded peptide. (J:290419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l1 Mutation: 108 strains or lines available

References

• Original: J:290419 Nakamura M, et al., Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight. 2016 Apr 21;1(5):e86217
• All: 2 reference(s)