Ace2^tm1(ACE2)Bhk
Targeted Allele Detail

Summary

• Symbol: Ace2^tm1(ACE2)Bhk
• Name: angiotensin converting enzyme 2; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:7550756
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^tm1(ACE2)Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337542
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ace2^tm1(ACE2)Bhk expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The targeting construct replaced the coding sequence through exon 18 with the human gene coding sequence. (J:337542)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 54 strains or lines available

Notes

ES cells = Phnx43 (129S6/SvEvTac)

References

• Original: J:337542 Snouwaert JN, et al., Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements. PLoS Pathog. 2023 Feb;19(2):e1011168
• All: 1 reference(s)