Mapk6^tm3Melo
Targeted Allele Detail

Summary

• Symbol: Mapk6^tm3Melo
• Name: mitogen-activated protein kinase 6; targeted mutation 3, Sylvain Meloche
• MGI ID: MGI:7550412
• Synonyms: Mapk6^flox
• Gene: Mapk6 Location: Chr9:75294064-75317303 bp, - strand Genetic Position: Chr9, 42.3 cM, cytoband E1
• Alliance: Mapk6^tm3Melo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294106
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. This creates a conditional-ready allele with exon 3 (which encodes kinase subdomains VIII and IX) floxed. (J:294106)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk6 Mutation: 29 strains or lines available

References

• Original: J:294106 Soulez M, et al., Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Mol Cell Biol. 2019 Mar 15;39(6)
• All: 1 reference(s)