Grk1^tm1.1Elrw
Targeted Allele Detail

Summary

• Symbol: Grk1^tm1.1Elrw
• Name: G protein-coupled receptor kinase 1; targeted mutation 1.1, Ellen R Weiss
• MGI ID: MGI:7550399
• Synonyms: GRK1-Ser21A
• Gene: Grk1 Location: Chr8:13455081-13471951 bp, + strand Genetic Position: Chr8, 5.93 cM, cytoband A2
• Alliance: Grk1^tm1.1Elrw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296511
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Serine codon 21 (AGT) in exon 1 was changed to alanine (p.S21A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 1. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation prevents phosphorylation of the affected residue in the encoded peptide. (J:296511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grk1 Mutation: 33 strains or lines available

References

• Original: J:296511 Kolesnikov AV, et al., Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors. FASEB J. 2020 Feb;34(2):2677-2690
• All: 1 reference(s)