Setd2^em1.1Appsc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Setd2^em1.1Appsc
• Name: SET domain containing 2; endonuclease-mediated mutation 1.1, Applied StemCell
• MGI ID: MGI:7550392
• Synonyms: Setd2^fl
• Gene: Setd2 Location: Chr9:110361368-110447703 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^em1.1Appsc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT-flanked PGK-neomycin cassette and second loxP site were inserted downstream of exon 7 via CRISPR/Cas9 technology. The PGK-neomycin cassette was removed via flp-mediated recombination leaving exons 6-7 floxed. (J:313451)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:313451 Xu L, et al., Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv. 2021 Jan;7(1)
• All: 1 reference(s)