Fgfr2^em2Sor
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fgfr2^em2Sor
• Name: fibroblast growth factor receptor 2; endonuclease-mediated mutation 2, Philippe Soriano
• MGI ID: MGI:7549361
• Synonyms: Fgfr2^FCPGT
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^em2Sor page

Mutation origin

• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced point mutations ablating the recruitment of FRS2, CRK, SHB/PLCgamma, and GRB14 along with the C -terminal truncation (FCPGT). (J:338808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 88 strains or lines available

References

• Original: J:338808 Clark JF, et al., FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development. Biol Open. 2023 Jul 7;12(7)
• All: 1 reference(s)