Fasn^tm1.1Mmats
Targeted Allele Detail

Summary

• Symbol: Fasn^tm1.1Mmats
• Name: fatty acid synthase; targeted mutation 1.1, Michihiro Matsumoto
• MGI ID: MGI:7549097
• Synonyms: F
• Gene: Fasn Location: Chr11:120696672-120715373 bp, - strand Genetic Position: Chr11, 84.56 cM
• Alliance: Fasn^tm1.1Mmats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin cassette was inserted upstream of exon 4 and third loxP site was inserted downstream of exon 10. The neomycin cassette was removed via cre-mediated recombination leaving exons 4-10 floxed. (J:342501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasn Mutation: 89 strains or lines available

References

• Original: J:342501 Matsukawa T, et al., Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models. JCI Insight. 2023 Sep 8;8(17)
• All: 1 reference(s)