Hprt1^{tm5(CAG-Foxf1,-EGFP)Akis}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm5(CAG-Foxf1,-EGFP)Akis}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, Andreas Kispert
• MGI ID: MGI:7548794
• Synonyms: Hprt^Foxf1, Hprt^{tm1(CAG-Foxf1,-EGFP)Akis}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm5(CAG-Foxf1,-EGFP)Akis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244068
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Hprt1^{tm5(CAG-Foxf1,-EGFP)Akis} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Foxf1 (MGI:1347470)

• Hprt1^{tm5(CAG-Foxf1,-EGFP)Akis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  cytomegalovirus	CMV

• Mutation details: Mutant mice express full length mouse Foxf1 under the control of the CMV promoter. This coding region was followed by a fragment harboring an IRES-GFP sequence to allow visualization of misexpressing cells. The bicistronic transgene cassette was integrated in the ubiquitously expressed X-chromosomal Hypoxanthine guanine phosphoribosyl transferase (Hprt) locus. (J:244068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:244068 Bohnenpoll T, et al., A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development. PLoS Genet. 2017 Aug;13(8):e1006951
• All: 2 reference(s)