Esr1^tm3.1Ics
Targeted Allele Detail

Summary

• Symbol: Esr1^tm3.1Ics
• Name: estrogen receptor 1 (alpha); targeted mutation 3.1, Mouse Clinical Institute
• MGI ID: MGI:7548550
• Synonyms: R264A-ERalpha
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm3.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302599
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Arginine 264 (CGA) in exon 5 was changed to alanine (GCA) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 5. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation abrogates the rapid dilation of mesenteric arteries and the acceleration of endothelial repair of carotid actions of the encoded peptide without affecting other functions. (J:302599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 69 strains or lines available

References

• Original: J:302599 Adlanmerini M, et al., Mutation of Arginine 264 on ERalpha (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2143-2158
• All: 3 reference(s)