Gt(ROSA)26Sor^{em2(CAG-GREB1_i4)Osb}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em2(CAG-GREB1_i4)Osb}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7548341
• Synonyms: GREB1 Is4 Tg, Gt(ROSA)26Sor^{em1(CAG-GREB1_i4)Akiki}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em2(CAG-GREB1_i4)Osb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342126
• Parent Cell Line: EGR-101 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted into the locus a CAG promoter, floxed triple STOP cassette, and a FLAG and HA-tagged isoform 4 of human gene. (J:342126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:342126 Shinzawa K, et al., GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation. Oncogene. 2023 Oct;42(42):3142-3156
• All: 1 reference(s)