Tg(Myh6-Mybpc3*)34Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mybpc3*)34Rbns
• Name: transgene insertion 34, Jeffrey Robbins
• MGI ID: MGI:7547411
• Synonyms: MyBP-C^AllP+
• Transgene: Tg(Myh6-Mybpc3*)34Rbns Location: unknown
• Alliance: Tg(Myh6-Mybpc3*)34Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mybpc3*)34Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mybpc3 (MGI:102844)	Expresses a constitutively phosphorylated form

• Tg(Myh6-Mybpc3*)34Rbns expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: A mutated mouse Mybpc3 cDNA is expressed under the control of a mouse alpha-MHC promoter. The Mybpc3 phosphorylation sites (Ser-273, Ser-282, Ser-302) were converted to aspartate, and a sequence encoding the myc epitope was added to the construct. Approximately 35% replacement with constitutively phosphorylated cMyBP-C AllP+ occurred in line 34. t (J:117119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117119 Sadayappan S, et al., Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16918-23
• All: 8 reference(s)