Tg(Myh6-Mybpc3*)262Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mybpc3*)262Rbns
• Name: transgene insertion 262, Jeffrey Robbins
• MGI ID: MGI:7547405
• Synonyms: MyBP-C^AllP-
• Transgene: Tg(Myh6-Mybpc3*)262Rbns Location: unknown
• Alliance: Tg(Myh6-Mybpc3*)262Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mybpc3*)262Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mybpc3 (MGI:102844)

• Tg(Myh6-Mybpc3*)262Rbns expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: A mutated mouse Mybpc3 cDNA is expressed under the control of a mouse alpha-MHC promoter. The Mybpc3 phosphorylation sites (Ser-273, Ser-282, Ser-302), along with two adjacent sites that could be potentially phosphorylated (Thr-272, Thr-281) were converted to alanine, and a sequence encoding the myc epitope was added to the construct. Lines 45, 262 and 272 were generated, but line 262 was selected for further study. (J:117505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117505 Sadayappan S, et al., Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res. 2005 Nov 25;97(11):1156-63
• All: 8 reference(s)