Ripk1^tm1.1Dov
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1.1Dov
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, Domagoj Vucic
• MGI ID: MGI:7547324
• Synonyms: Ripk1^cko
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1.1Dov page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional ready allele with exon 2 floxed. (J:303001)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 32 strains or lines available

References

• Original: J:303001 Kist M, et al., Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death. Cell Death Differ. 2021 Mar;28(3):985-1000
• All: 1 reference(s)