Trp53^tm1.1Ypz
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Ypz
• Name: transformation related protein 53; targeted mutation 1.1, Yangping Zhang
• MGI ID: MGI:7547169
• Synonyms: p53 K316P
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Ypz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340332
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct introduced the mutation responsible for the amino acid substitution of lysine with proline at position 316 (K316P). Flp-mediated recombination removed the selection cassette. (J:340332)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:340332 Sanford JD, et al., A role of cytoplasmic p53 in the regulation of metabolism shown by bat-mimicking p53 NLS mutant mice. Cell Rep. 2023 Jan 31;42(1):111920
• All: 1 reference(s)