Tor1a^tm1Rbro
Targeted Allele Detail

Summary

• Symbol: Tor1a^tm1Rbro
• Name: torsin family 1, member A (torsin A); targeted mutation 1, Robert M Brownstone
• MGI ID: MGI:7547122
• Synonyms: Tor1a-frt
• Gene: Tor1a Location: Chr2:30850639-30857945 bp, - strand Genetic Position: Chr2, 21.77 cM
• Alliance: Tor1a^tm1Rbro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340335
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct flanked exons 3 to 5 with FRT sites and inserted a loxP flanked neomycin resistance cassette. (J:340335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tor1a Mutation: 22 strains or lines available

References

• Original: J:340335 Pocratsky AM, et al., Pathophysiology of Dyt1-Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction. Sci Transl Med. 2023 May 3;15(694):eadg3904
• All: 1 reference(s)