Hdac2^em1Eom
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdac2^em1Eom
• Name: histone deacetylase 2; endonuclease-mediated mutation 1, Gwang Hyeon Eom
• MGI ID: MGI:7546996
• Synonyms: HDAC2 2CA
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^em1Eom page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination changed the coding sequence for cysteines 262 and 274 to alanines. The resulting protein is predicted to be S-nitrosylation dead. (J:342202)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 39 strains or lines available

References

• Original: J:342202 Yoon S, et al., S-Nitrosylation of Histone Deacetylase 2 by Neuronal Nitric Oxide Synthase as a Mechanism of Diastolic Dysfunction. Circulation. 2021 May 11;143(19):1912-1925
• All: 1 reference(s)