Cnr2^tm2.1Itl
Targeted Allele Detail

Summary

• Symbol: Cnr2^tm2.1Itl
• Name: cannabinoid receptor 2; targeted mutation 2.1, Ingenious Targeting Laboratory
• MGI ID: MGI:7546835
• Synonyms: Cnr2^f
• Gene: Cnr2 Location: Chr4:135622705-135647518 bp, + strand Genetic Position: Chr4, 68.01 cM
• Alliance: Cnr2^tm2.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341073
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a flanked coding exon with an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:341073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr2 Mutation: 24 strains or lines available

References

• Original: J:341073 Liu QR, et al., Low Basal CB2R in Dopamine Neurons and Microglia Influences Cannabinoid Tetrad Effects. Int J Mol Sci. 2020 Dec 21;21(24)
• All: 1 reference(s)