Tg(Fap-cre)#Rkl
Transgene Detail

Summary

• Symbol: Tg(Fap-cre)#Rkl
• Name: transgene insertion, Raghu Kalluri
• MGI ID: MGI:7546824
• Synonyms: FAP-Cre
• Transgene: Tg(Fap-cre)#Rkl Location: unknown
• Alliance: Tg(Fap-cre)#Rkl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Fap-cre)#Rkl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fap (MGI:109608)

• Mutation details: The transgenic construct contains a 5 kb sequence including the Fap (fibroblast activation protein) promoter and part of exon 1 inserted into the pORF-FAP-TK vector to replace the full coding sequence of the Herpes simplex virus thymidine kinase with a cre expression cassette. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:325566)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fap (mouse) Summary of all recombinase alleles driven by Fap. Alliance mouse Fap gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:325566 McAndrews KM, et al., Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 2022 Jun 2;12(6):1580-1597
• All: 1 reference(s)