Trpm4^tm1.2Abrie
Targeted Allele Detail

Summary

• Symbol: Trpm4^tm1.2Abrie
• Name: transient receptor potential cation channel, subfamily M, member 4; targeted mutation 1.2, Hugues Abriel
• MGI ID: MGI:7546817
• Synonyms: Trpm4tm1.2-PG
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^tm1.2Abrie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of exon 10 an FRT site, lacZ, loxP, neomycin resistance cassette, and FRT site. A second loxP site was inserted downstream of exon 10. Flp- and cre-mediated recombination removed the reporter, selection cassette, and exon 10. (J:341087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 58 strains or lines available

References

• Original: J:341087 Arullampalam P, et al., Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice. Physiol Rep. 2023 Aug;11(16):e15783
• All: 1 reference(s)