Fto^em1Hbgl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fto^em1Hbgl
• Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Hua-Bing Li
• MGI ID: MGI:7545694
• Synonyms: Fto^flox
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^em1Hbgl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/Cas9 technology inserted loxP sites to generate a floxed allele. (J:338683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:338683 Zhou J, et al., m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity. Sci Adv. 2021 Jun;7(25)
• All: 1 reference(s)