Mir100hg^tm1.1Arod
Targeted Allele Detail

Summary

• Symbol: Mir100hg^tm1.1Arod
• Name: Mir100 Mirlet7a-2 Mir125b-1 cluster host gene; targeted mutation 1.1 Antony Rodriguez
• MGI ID: MGI:7545323
• Synonyms: let-7a2^-;miR-100^-
• Gene: Mir100hg Location: Chr9:41287822-41526481 bp, + strand Genetic Position: Chr9, 23.32 cM
• Alliance: Mir100hg^tm1.1Arod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272391
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector containing a loxP flanked PGK-EM7-NeobpA cassette replaced Mir100 and Mirlet7a-2, two of the mRNAs in the Mir100hg cluster. Cre-mediated recombination removed the neo cassette. (J:236467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir100hg Mutation: 0 strains or lines available

References

• Original: J:272391 Robinton DA, et al., The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell. 2019 Feb 11;48(3):396-405.e3
• All: 2 reference(s)