Elac2^tm1.1Afi
Targeted Allele Detail

Summary

• Symbol: Elac2^tm1.1Afi
• Name: elaC ribonuclease Z 2; targeted mutation 1.1, Aleksandra Filipovska
• MGI ID: MGI:7545034
• Synonyms: ELAC2 KO
• Gene: Elac2 Location: Chr11:64869864-64892895 bp, + strand Genetic Position: Chr11, 40.42 cM, cytoband B3
• Alliance: Elac2^tm1.1Afi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 7 and a second loxP site into intron 8. The neo cassette was removed through Flp-mediated recombination, leaving a conditional allele with exon 8 floxed. (J:336403)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elac2 Mutation: 40 strains or lines available

References

• Original: J:336403 Stentenbach M, et al., Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. EMBO Mol Med. 2023 Jun 7;15(6):e17463
• All: 1 reference(s)