Mirc8^tm1.1Arod
Targeted Allele Detail

Summary

• Symbol: Mirc8^tm1.1Arod
• Name: microRNA cluster 8, including Mirlet7d, Mirlet7f-1, and Mirlet7a-1; targeted mutation 1.1 Antony Rodriguez
• MGI ID: MGI:7544869
• Synonyms: let-7a1^-;let-7d->;let-7f1<->, let-7 KO strain 2
• Gene: Mirc8 Location: unknown Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272391
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector containing a loxP flanked PGK-EM7-NeobpA cassette replaced Mirlet7d, Mirlet7f-1, and Mirlet7a-1 which make up the Mirc8 cluster. Cre-mediated recombination removed the neo cassette. (J:236467, J:272391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc8 Mutation: 3 strains or lines available

References

• Original: J:272391 Robinton DA, et al., The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell. 2019 Feb 11;48(3):396-405.e3
• All: 4 reference(s)