Nos2^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nos2^em1Smoc
• Name: nitric oxide synthase 2, inducible; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7543918
• Synonyms: Mcm8^-
• Gene: Nos2 Location: Chr11:78811613-78851052 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Nos2^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Exon12-13 of Nos2 gene were deleted to generate Nos2 knockout mice. (J:238766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nos2 Mutation: 66 strains or lines available

References

• Original: J:341798 Lin M, et al., MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease. Nat Cardiovasc Res. 2023;2(8):778-792
• All: 2 reference(s)