Dhfr^em1Davy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dhfr^em1Davy
• Name: dihydrofolate reductase; endonuclease-mediated mutation 1, Alice Davy
• MGI ID: MGI:7543775
• Synonyms: Dhfr^delta
• Gene: Dhfr Location: Chr13:92491291-92525561 bp, + strand Genetic Position: Chr13, 47.64 cM
• Alliance: Dhfr^em1Davy page

Mutation origin

• Strain of Origin: 129S4/SvJae and C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated an 844 bp deletion corresponding to exon 5. (J:341708)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhfr Mutation: 18 strains or lines available

References

• Original: J:341708 Saha S, et al., Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. Development. 2023 Oct 15;150(20):dev201696
• All: 1 reference(s)