Del(18Dsg1c-Dsg1b)1Awar
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(18Dsg1c-Dsg1b)1Awar
• Name: deletion, Chr 18, Rajeshwar Awatramani 1
• MGI ID: MGI:7543307
• Synonyms: Dsg1^-
• Gene: Del(18Dsg1c-Dsg1b)1Awar Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(18Dsg1c-Dsg1b)1Awar involves 3 genes/genome features (Dsg1c, Dsg1a, Dsg1b) View all
• Mutation details: CRISPR/Cas9 technology deleted the approximately 170 kb desmoglein 1 tandem gene cluster which includes Dsg1c, Dsg1a and Dsg1b. Sequence analysis confirmed the loss of the Dsg1 gene cluster. (J:320249)

Expression

In Mice Carrying this Mutation:

2 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(18Dsg1c-Dsg1b)1Awar Mutation: 0 strains or lines available

References

• Original: J:320249 Godsel LM, et al., Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest. 2022 Feb 1;132(3):e144363
• All: 2 reference(s)